The Organization Without a Cool Acronym (O.W.C.A) is an organization consisting mostly of animal agents that fight evil. The best-known agent in O.W.C.A. is Agent P, the platypus agent from Phineas and Ferb. The organization's leader is Major Monogram.
In "The Ticking Clock", Monogram and Carl argue about Carl's new glasses and give Perry the task of watching over Doof's new "Do Good-Inators".
In "Sick Day", Perry is assigned by Monogram, in person, to watch over Doof and his destructive "Do Good-Inator". Monogram then accidentally reveals that Perry has been getting payed to hang out with Doof. Doof then gets angry at Perry and shoves him out of his life.
In "Milo in Space", Carl detects the Octalians ships passing through the Earth's atmosphere. Monogram is alarmed and is about to assign an agent on the mission, but realizes that it's 5 o'clock and he and Carl break for lunch and leave the headquarters. Later, Perry tries to save Milo from the Octalians grasp, but fails. Perry and Doof later make up and become friends again. Perry then helps the gang get the ship in the air.